FREQUENT COEXISTENCE OF GLI1 OVEREXPRESSION AND BRAF(V600E) MUTATION IN AMELOBLASTOMAS
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چکیده
منابع مشابه
Disseminated histiocytoses biomarkers beyond BRAFV600E: frequent expression of PD-L1
The histiocytoses are rare tumors characterized by the primary accumulation and tissue infiltration of histiocytes and dendritic cells. Identification of the activating BRAFV600E mutation in Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) cases provided the basis for the treatment with BRAF and/or MEK inhibitors, but additional treatment options are needed. Twenty-four cas...
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Purpose/Aim of the study: BRAFV600E is an oncogenic point mutation in the MAPK/ERK signaling pathway, which is important for cell proliferation and migration. It has been found to be associated with several malignancies and has also been found in significant proportions of patients with Langerhans cell histiocytosis. A recent mouse model which introduces the BRAFV600E mutations only into dendri...
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BACKGROUND The BRAFV600E mutation is the most common genetic alteration in papillary thyroid carcinoma (PTC). In recent studies, the BRAFV600E mutation has been associated with poor clinicopathological characteristics, such as lymph node metastasis, extrathyroidal extension, and advanced stage. However, other studies have failed to establish an association between the BRAFV600E mutation and cli...
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ژورنال
عنوان ژورنال: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
سال: 2019
ISSN: 2212-4403
DOI: 10.1016/j.oooo.2019.02.078